HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → HCID 57388226, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 6-Fluoro-2-methyl-1H-indole | HCID 9942185 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 57388226 | HCID 57388226 | 93.7% |
Reaction Steps
The product is prepared by following the procedure described in reference example 2c (step 1c) using 1.4 g of 6-fluoro-2-methylindole, 51 ml of acetic acid and 1.9 g of sodium cyanoborohydride. After silica column purification, eluent: 90/10 heptane/ethyl acetate, 1.33 g of 6-fluoro-2-methyl-2,3-dihydro-1H-indole are obtained, which is used as it is in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133168B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-c24e0d3d68c44b6ba24893ff05b1c35e |
| Source note | uspto-grants-2015_09 |