Pyridine → HCID 136069606, compound

Participants

Reaction Steps

0.105 ml of pyridine and 165 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride are successively added to a solution of 170 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (example 1d, step 2d) in 3 ml of N,N-dimethylformamide. After stirring at ambient temperature for 15 minutes, 140 mg of 4-(2-methoxyphenyl)-2,3-dihydro-1H-indole (reference example 3d) are added. The reaction mixture is stirred at ambient temperature for 16 hours, and then 20 ml of water and 3 ml of ethyl acetate are added. After stirring at ambient temperature for 1 hour, the precipitate formed is filtered off, and then rinsed successively with water and diethyl ether. After drying under reduced pressure at 40° C., 202 mg of 2-{2-[4-(2-methoxyphenyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pale pink solid, the characteristics of which are the following:

Provenance & Evidence