HCID 13276700, compound → HCID 136069610, compound

HRID 2278622Notes

Reaction equation

HRID 2278622 reaction equation
[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([O-:17])=O)[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Na+].[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]1[CH:33]=[CH:32][CH:31]=[C:30]2[C:26]=1[CH2:27][CH2:28][NH:29]2>>[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15](=[O:17])[N:29]3[C:30]4[C:26](=[C:25]([C:20]5[CH:21]=[CH:22][CH:23]=[CH:24][N:19]=5)[CH:33]=[CH:32][CH:31]=4)[CH2:27][CH2:28]3)[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 13276700HCID 13276700, compoundHCID 136041844Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

Product 1

HCID 136069610HCID 136069610, compoundYield 62.8%

Procedure

The product is prepared by following the procedure described in example 10d using 26.7 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (example 1d, step 2d) and 25 mg of 4-pyridin-2-yl-2,3-dihydro-1H-indole in place of 4-pyridin-4-yl-2,3-dihydro-1H-indole. 26.8 mg of 6-(morpholin-4-yl)-2-{2-oxo-2-[4-(pyridin-2-yl)-2,3-dihydro-1H-indol-1-yl]ethyl}pyrimidin-4(3H)-one are obtained in the form of a purple solid, the characteristics of which are the following:

Workup

  1. customThe product is prepared

Sources & evidence

ORD record
ord-da4612234d164b9d85491ca7a9af4dd9
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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