1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 136069612, compound

Participants

Reaction Steps

300 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (example 1d, step 2d), 330 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 6 ml of pyridine are successively added to a solution of 264 mg of 4-(2-chlorophenyl)-2,3-dihydro-1H-indole (reference example 6d) in 5 ml of pyridine. The reaction mixture is stirred at ambient temperature for 4 days. The reaction medium is diluted with ethyl acetate (60 ml) and then successively washed with an aqueous 1M hydrochloric acid solution, an aqueous 1M sodium hydroxide solution, and a saturated aqueous sodium chloride solution. The organic phase is then dried over magnesium sulfate and filtered through sintered glass. A precipitate appears after a few hours, which is then filtered off through sintered glass and washed with diethyl ether. 294 mg of 2-{2-[4-(2-chlorophenyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a beige solid, the characteristics of which are the following:

Provenance & Evidence