1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 136378694, compound

Participants

Reaction Steps

225 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride and 196 mg of 2-methyl-4-trifluoromethyl-2,3-dihydro-1H-indole are added to a solution of 259 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (example 1d, step 2d) in 3 ml of N,N-dimethylformamide and 3 ml of pyridine. The reaction mixture is stirred at ambient temperature for 20 hours and then diluted with water and extracted with ethyl acetate. The extracts are washed successively with water, a hydrochloric acid solution (1M), water and a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate, filtered, and concentrated under reduced pressure, so as to give 144 mg of 2-[2-(2-methyl-4-trifluoromethyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one in the form of a white solid.

Provenance & Evidence