反应详情

The product is prepared by following the procedure described in example 1e (step 4e) using 200 mg of sodium (4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)acetate obtained in example 1e (step 2e) and 106 mg of (R)-2-methyl-2,3-dihydro-1H-indole (which can be prepared according to Krasnov, V. P. et al. (Mendeleev Commun. 2002, 12(1), 27-28)). After purification by silica column chromatography (eluent: 98/02 dichloromethane/ethyl dichloromethane), 71 mg of 1-((R)-2-methyl-2,3-dihydroindol-1-yl)-2-(4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)ethanone are obtained in the form of a white powder, the characteristics of which are the following:

1. customThe product is prepared
2. customAfter purification by silica column chromatography (eluent: 98/02 dichloromethane/ethyl dichloromethane), 71 mg of 1-((R)-2-methyl-2,3-dihydroindol-1-yl)-2-(4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)ethanone
3. customare obtained in the form of a white powder