3-Fluoro-4-formylbenzonitrile → HCID 86719432, compound

HRID 2278691Notes

Reaction equation

HRID 2278691 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH:10]=O)[C:5]#[N:6].[C:12]([CH2:14][C@@H:15]1[N:19]([C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[N:18]=[C:17](C2C=CC(C#N)=CC=2)[C@H:16]1C)#[N:13]>>[C:12]([CH2:14][C@@H:15]1[N:19]([C:20]2[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=2)[N:18]=[C:10]([C:9]2[CH:8]=[CH:7][C:4]([C:5]#[N:6])=[CH:3][C:2]=2[F:1])[C@H:16]1[CH3:17])#[N:13]

Participants

3

Reactant 2

HCID 27831503-Fluoro-4-formylbenzonitrileHCID 867194294-((4S,5S)-5-(cyanomethyl)-1-(4-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazol-3-yl)benzonitrile

Product 1

HCID 86719432HCID 86719432, compound

Procedure

4-((4S,5S)-5-(Cyanomethyl)-1-(4-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazol-3-yl)-3-fluorobenzonitrile was prepared from 3-fluoro-4-formylbenzonitrile following the procedure for the preparation of 4-((4S,5S)-5-(cyanomethyl)-1-(4-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazol-3-yl)benzonitrile (91G): LC-MS [M+H] 335.

Sources & evidence

ORD record
ord-eb128a19bc8b4565870259aeca62b508
Source dataset
uspto-grants-2015_09
Patent number
US09133163B2

Reaction notes

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