Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Tolylboronic acid | HCID 79799 | — |
| Reactant | 3-Bromo-5-iodobenzoic acid | HCID 5182520 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 58449378 | HCID 58449378 | — |
Reaction Steps
A pressure vial was charged with 3-bromo-5-iodo-benzoic acid (7.60 g, 23.2 mmol), p-tolylboronic acid (3.16 g, 23.2 mmol), tetrakis(triphenylphosphine)palladium(0) (1.34 g, 1.16 mmol), cesium carbonate (8.33 g, 25.6 mmol), toluene (99.0 mL, 930 mmol), ethanol (27.1 mL, 465 mmol) and water (12.6 mL, 697 mmol) and the reaction stirred at 85° C. over nights. The reaction mixture was filtered over celite and the solvent removed to get the crude product as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09133122B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-bed884a083644b15b3a3ca72c74dbdd7 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
