HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 3-iodo-5-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Iodo-5-nitrobenzoic acid | HCID 80580 | — |
| Product | Methyl 3-iodo-5-nitrobenzoate | HCID 7020599 | — |
Reaction Steps
To a stirred solution of 3-iodo-5-nitrobenzoic acid (15.1 g, 0.049 mol) in methanol (151 mL, 3.73 mol) was added thionyl chloride (15.1 mL, 0.205 mol) dropwise at 0° C. The mixture was heated to reflux for 2 hours. The solvent was removed in vacuo. The residue was purified by flash chromatography (0-100% EtOAc/hexane) to afford an white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133122B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-230ff938fff145e8adf65166834106d1 |
| Source note | uspto-grants-2015_09 |