HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 67304388, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (6-Methylpyridin-3-yl)methanamine | HCID 12214337 | — |
| Reactant | HCID 58449374 | HCID 58449374 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | HCID 67304388 | HCID 67304388 | — |
Reaction Steps
A round bottom flask was charged with 3-bromo-5-(5-methylpyridin-2-yl)benzoic acid (450.00 mg, 1.5404 mmol), (6-methylpyridin-3-yl)methanamine (225.83 mg, 1.8485 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (1171.4 mg, 3.0808 mmol), N,N-diisopropylethylamine (0.93910 mL, 5.3915 mmol) and N,N-dimethylformamide (5.00 mL, 64.6 mmol) and the reaction stirred at room temperature for 1 hour. The reaction was poured into brine and extracted with ethyl acetate to get the product as brown solid
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133122B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-20f64d4680cb43d2b4718cabc50d1c94 |
| Source note | uspto-grants-2015_09 |