HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2278745Generated: October 30, 2026
Diisopropylethylamine → HCID 45137636, compound
https://huagongshe.com/reaction/2278745
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (6-Methylpyridin-3-yl)methanamine | HCID 12214337 | — |
| Reactant | HCID 67304633 | HCID 67304633 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 45137636 | HCID 45137636 | — |
Reaction Steps
To a solution of 4′-methyl-5-(2-oxopyrrolidin-1-yl)biphenyl-3-carboxylic acid (53.0 mg, 0.000152 mol) in N,N-dimethylformamide (1 mL, 0.01 mol) was added (6-methylpyridin-3-yl)methanamine (45.0 mg, 0.000368 mol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (150.0 mg, 0.0003945 mol) and N,N-diisopropylethylamine (150.0 uL, 0.0008612 mol). The reaction mixture was stirred for 16 hours at 25° C. Checked LC/MS, the reaction was completed. The DMF reaction solution was directly applied to prep. HPLC. The final product was yield a light color foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09133122B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-3249919d5e0c4ba485e457dd5217a053 |
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| Source note | uspto-grants-2015_09 |
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