Potassium Carbonate → HCID 58449375, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-bromo-5-iodo-N-((6-methylpyridin-3-yl)methyl)benzamide (250 mg, 0.58 mmol), L-prolinol (88 mg, 0.87 mmol), potassium carbonate (160 mg, 1.2 mmol), L-proline (13 mg, 0.12 mmol), and copper(I) iodide (11 mg, 0.058 mmol) in dimethyl sulfoxide (2 mL) under nitrogen was stirred at 90° C. for 10 h. The cooled mixture was partitioned between water and ethyl acetate. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried (Na2SO4), and concentrated in vacuo. The residue was purified by silica gel column (EtOAc/hexane: 0-100%) to afford a white foam.

Provenance & Evidence