Hydroxyamine hydrochloride → HCID 178467977, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-chloro-4-(2,2-diethoxyethoxy)-5-methylbenzonitrile (4.54 g, 16.0 mmol) in methanol (50 mL), hydroxylamine hydrochloride (3.34 g, 48.0 mmol) and NaHCO3 (2.69 g, 32.0 mmol) is added. The mixture is stirred at 75° C. for 2 h before it is diluted with EA (120 mL) and washed with water (100 mL). The washing is extracted twice with EA (2×75 mL). The combined org. extracts are dried over MgSO4, filtered and concentrated to give the title compound (4.43 g) as a beige wax which slowly solidifies upon standing; LC-MS: tR=0.55 min, [M+1]+=317.28.

Provenance & Evidence