HCID 70558026, compound → HCID 57524378, compound

Participants

Reaction Steps

A solution of ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methyl-phenoxy)ethyl)amino)propanoate (88 mg, 0.168 mmol) in MeOH (0.5 mL), THF (0.5 mL) and 2 N aq. LiOH (0.2 mL) is stirred at rt for 2 h. The mixture is concentrated, diluted with 2 N aq. HCl (10 mL) and extracted four times with DCM (4×20 mL). The combined org. extracts are dried over MgSO4, filtered and concentrated. The crude product is purified by prep. HPLC to give the title compound (63 mg) as an off-white solid; LC-MS: tR=0.93 min, [M+H]+=495.12; 1H NMR (CDCl3): δ 8.37 (s br, 2H), 7.78 (s, 1H), 7.72 (s, 1 H), 7.43 (s, 1H), 7.20 (s, 1H), 4.07-4.18 (m, 2H), 3.99 (s, 3H), 3.34-3.42 (m, 2H), 3.16-3.34 (m, 3H), 2.62-2.76 (m, 4H), 2.33 (s, 3H), 2.09 (m, 2H), 1.81-1.94 (m, 4H), 1.68-1.79 (m, 2H), 1.27 (t, J=7.5 Hz, 3H).

Provenance & Evidence