Methyl azetidine-3-carboxylate hydrochloride → HCID 57524621, compound

Participants

Reaction Steps

The title compound (29 mg) is prepared as a white solid in analogy to the procedures given in Example 1 starting from 3-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propyl methanesulfonate (150 mg, 0.291 mmol) and azetidine-3-carboxylic acid methyl ester hydrochloride (220 mg, 1.46 mmol); LC-MS: tR=0.96 min, [M+H]+=521.39; 1H NMR (CD3OD): δ 7.89 (d, J=1.4 Hz, 1H), 7.87 (d, J=1.4 Hz, 1H), 7.55 (d, J=1.0 Hz, 1H), 7.31 (d, J=1.1 Hz, 1H), 4.24-4.40 (m, 4H), 4.01 (s, 3H), 3.97 (t, J=5.8 Hz, 2H), 3.53-3.60 (m, 2H), 3.43-3.48 (m, 1H), 3.26-3.31 (m, 1H), 2.78 (q, J=7.5 Hz, 2H), 2.41 (s, 3H), 2.06-2.19 (m, 4H), 1.86-1.97 (m, 4H), 1.72-1.83 (m, 2H), 1.33 (t, J=7.5 Hz, 3H).

Provenance & Evidence