Glycine ethyl ester → HCID 57523796, compound

HRID 2278803Notes

Reaction equation

HRID 2278803 reaction equation
[CH:1]1([C:6]2[CH:7]=[C:8]([CH:12]=[C:13]([O:15][CH3:16])[N:14]=2)[C:9]([OH:11])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:17][C:18]1[CH:19]=[C:20]([CH:25]=[C:26]([O:35][CH3:36])[C:27]=1[O:28][CH2:29][CH:30](OC)OC)[C:21](=[NH:24])[NH:22]O.[NH2:37][CH2:38][C:39]([O:41]CC)=[O:40]>>[Cl:17][C:18]1[CH:19]=[C:20]([C:21]2[N:22]=[C:9]([C:8]3[CH:12]=[C:13]([O:15][CH3:16])[N:14]=[C:6]([CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5]4)[CH:7]=3)[O:11][N:24]=2)[CH:25]=[C:26]([O:35][CH3:36])[C:27]=1[O:28][CH2:29][CH2:30][NH:37][CH2:38][C:39]([OH:41])=[O:40]

Participants

4

Reactant 3

HCID 12176Glycine ethyl esterHCID 58418037HCID 58418037, compoundHCID 178492428HCID 178492428, compound

Product 1

HCID 57523796HCID 57523796, compound

Procedure

The title compound is prepared starting from 2-cyclopentyl-6-methoxy-isonicotinic acid, 3-chloro-4-(2,2-dimethoxyethoxy)-N-hydroxy-5-methoxybenzimidamide and ethyl glycinate in analogy to Example 43 and 1 (saponification); LC-MS: tR=0.88 min, [M+H]+=503.11.

Sources & evidence

ORD record
ord-c8db862cead94c37aabb38d52bc1fb87
Source dataset
uspto-grants-2015_09
Patent number
US09133179B2

Reaction notes

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