Diisopropylethylamine → HCID 131733471, compound

Participants

Reaction Conditions

Reaction Steps

2.0 g (5.39 mmol) Chas-D-Phe(4-NO2)—OH and 1.42 g (5.39 mmol) H-Phe(4-NO2)—OMe.HCl were suspended in 30 ml of DMF and 2.82 g (5.39 mmol) of PyBOP and 2.81 ml (16.16 mmol) of DIPEA was added at 0° C. After 2 h of stirring at 0° C., the solvent was removed in vacuo and the brown residue resuspended in 5% KHSO4 soln./EtOAc. The organic phase was washed 3× with 5%-KHSO4 soln., 1× with sat. NaCl soln., 3× with sat. NaHCO3-soln., and 3× with sat. NaCl soln., subsequently dried with MgSO4, filtered, and the solvent was removed in vacuo.

Provenance & Evidence