Ambroxol → (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid--4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol (1/1)

Participants

Reaction Conditions

Reaction Steps

The mixture of ambroxol base (378.1 g, 1 mole) and toluene (3000 ml) was heated at 60-65° C. for 1-2 minutes to prepare a clear solution. Toluene (1900 ml) and theophylline-7-acetic acid (238.2 g, 1 mole) were charged in a round bottom flask and heated at 75 to 80° C. To this flask, the prepared solution of ambroxol base in toluene was added under stirring while maintaining the temperature between 75-80° C. during 2-3 minutes. The resulting reaction mixture was stirred at 100-105° C. for 25-30 minutes. The reaction mixture was allowed to cool to room temperature. The separated solid product was filtered and washed with toluene and dried. The yield of Acebrophylline obtained was 98%.

Provenance & Evidence