反应详情

0.916 g (7.035 mmol) of methyl 2-oxopentanoate in 15 ml of ethanol were initially introduced and heated to reflux. Then, 2.000 g (7.035 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidohydrazide suspended in 20 ml of ethanol were added and the mixture was heated under reflux overnight. After cooling, the mixture was filtered off with suction, and the filtercake was washed with a little ethanol and dried under high vacuum. This gave 1.75 g of the target compound (purity 92%; 63% of theory).

1. temperatureheated to reflux
2. additionwere added
3. temperaturethe mixture was heated
4. temperatureunder reflux overnight
5. temperatureAfter cooling
6. filtrationthe mixture was filtered off with suction
7. washthe filtercake was washed with a little ethanol
8. customdried under high vacuum