HCID 66671494, compound → HCID 66671496, compound

HRID 2278873Notes

Reaction equation

HRID 2278873 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([C:11]#[C:12][CH:13]([OH:15])[CH3:14])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:16].[H][H]>[Pd].C(O)C>[NH2:1][C:2]1[N:10]=[C:9]([CH2:11][CH2:12][CH:13]([OH:15])[CH3:14])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:16]

Participants

5

Reactant 2

HCID 66671494HCID 66671494, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66671496HCID 66671496, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-(6-Amino-9-methyl-9H-purin-2-yl)but-3-yn-2-ol (1.5 g, 6.88 mmol) was placed in an autoclave with ethanol (30 ml) and palladium 10% on graphite (0.350 g, 20% in weight) was added. The mixture was stirred overnight under 4 atm of hydrogen at 50° C. The catalyst was filtered off through Celite and the resulting solution was evaporated under reduced pressure, to give a residue that was used without any further purification.

Workup

  1. additionwas added
  2. filtrationThe catalyst was filtered off through Celite
  3. customthe resulting solution was evaporated under reduced pressure
  4. customto give a residue that
  5. customwas used without any further purification

Sources & evidence

ORD record
ord-f6489f1a8bed419e8412ffb64069c79e
Source dataset
uspto-grants-2015_09
Patent number
US09133197B2

Reaction notes

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