Ammonia → HCID 66777001, compound

HRID 2278877Notes

Reaction equation

HRID 2278877 reaction equation
Cl[C:2]1[N:10]=[C:9]([CH:11]([OH:15])[CH2:12][CH2:13][CH3:14])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:16].O.[NH3:18]>O1CCOCC1>[NH2:18][C:2]1[N:10]=[C:9]([CH:11]([OH:15])[CH2:12][CH2:13][CH3:14])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:16]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 86662664HCID 86662664, compound

Product 1

HCID 66777001HCID 66777001, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
70 °C

Procedure

To the solution of 1-(6-chloro-9-methyl-9H-purin-2-yl)butan-1-ol (1.8 g, 7.47 mmol) in dioxane (10 ml) was added 30% w/w water solution of ammonia (20 ml). The reaction mixture was stirred overnight in an autoclave at 70° C. The solution was evaporated at atmospheric pressure at 50° C. and then under reduced pressure. The residue was purified by flash chromatography (DCM/MeOH: 95/5).

Workup

  1. customThe solution was evaporated at atmospheric pressure at 50° C.
  2. customThe residue was purified by flash chromatography (DCM/MeOH: 95/5)

Sources & evidence

ORD record
ord-c5b8baa98501439bb34c169520a79448
Source dataset
uspto-grants-2015_09
Patent number
US09133197B2

Reaction notes

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