HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → Ethyl 3-(dibenzylamino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 3-(dibenzylamino)propanoate | HCID 44791227 | 97% |
Reaction Steps
A solution of ethyl 3-aminopropanoate hydrochloride (80.0 g, 0.52 mol), benzylbromide (186.7 g, 1.1 mol) and K2CO3 (179.4 g, 1.3 mol) in MeCN (1 L) was heated at 40° C. overnight. The mixture was concentrated to dryness, poured into water, extracted with EtOAc (3×) and the combined organics were washed with brine, dried over Na2SO4 and purified via silica gel chromatography to give ethyl 3-(dibenzylamino)propanoate (150 g, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133183B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-e967364a5adb4228ae141c11dc6463b7 |
| Source note | uspto-grants-2015_09 |