2-Imidazolidinone → HCID 90427256, compound

Participants

Reaction Steps

A 0° C. solution of triphosgene (0.500 g, 1.685 mmol) in MeCN (10 mL) was treated with a solution of imidazolidin-2-one (0.800 g, 9.29 mmol) in MeCN (10 mL), stirred at RT for 0.5 h, added to a suspension of Example A2 (0.800 g, 2.99 mmol) in MeCN (10 mL) and stirred at RT for 4 h. The solids were collected via filtration to afford N-(5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)-2-oxoimidazolidine-1-carboxamide (862 mg, 76%) as an off-white solid. MS (ESI) m/z: 380.1 (M+H+).

Provenance & Evidence