HCID 90426625, compound → HCID 90426318, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(4-((2-ethyl-6-nitropyridin-3-yl)oxy)pyridin-2-yl)-2-methylthiazole (756 mg, 2.208 mmol) and 10% Pd/C (50% w/w with water, 235 mg, 0.221 mmol) in MeOH (15 mL) was hydrogenated (1 atm) at RT overnight, then warmed to 50° C. for 4 h. The mixture was cooled to RT, the solids removed via filtration through diatomaceous earth, washed with MeOH and the filtrate concentrated to dryness to afford 6-ethyl-5-((2-(2-methylthiazol-5-yl)pyridin-4-yl)oxy)pyridin-2-amine (79 mg, 11%). MS (ESI) m/z: 313.1 (M+H+).

Provenance & Evidence