HCID 131733477, compound → HCID 90426712, compound

Participants

Reaction Steps

tert-Butyl(4-(2-chloro-5-fluoro-4-(2-oxo-3-(tetrahydro-2H-pyran-4-yl)imidazolidine-1-carboxamido)phenoxy)pyridin-2-yl)carbamate (1.32 g, 2.400 mmol) was combined with TFA (20 mL), stirred at RT overnight and concentrated to dryness. The residue was treated with DCM, sonicated, the solid removed via filtration and the filtrate concentrated to dryness and purified via silica gel chromatography (MeOH/EtOAc) to afford N-(4-((2-aminopyridin-4-yl)oxy)-5-chloro-2-fluorophenyl)-2-oxo-3-(tetrahydro-2H-pyran-4-yl)imidazolidine-1-carboxamide (382 mg, 35%). MS (ESI) m/z: (M+H+): 450.1.

Provenance & Evidence