Hydrochloric Acid → HCID 67959033, compound

Participants

Reaction Steps

A mixture of tert-butyl (3R)-3-{[3-(2-methoxypyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl]-amino}piperidine-1-carboxylate (Preparation 3a, 0.1 g, 0.24 mmol) and a solution of hydrogen chloride in methanol (1.25 N solution, 4 mL) was stirred at ambient temperature for 5 hours. The reaction mixture was then carefully diluted with aqueous saturated sodium hydrogencarbonate solution and extracted with dichloromethane (×3). The organic layer was dried eluting through a Phase Separator® membrane and the solvent removed under reduced pressure to yield the title compound (0.08 g, 98%) as a yellow solid.

Provenance & Evidence