反应详情

温度

180 °C

A mixture of 3-bromo-6-chloroimidazo[1,2-b]pyridazine (Preparation 1b, 0.2 g, 0.86 mmol), (1S)-1-(5-fluoropyrimidin-2-yl)ethanamine (prepared according to the method described in WO2006/82392A1, 0.24 g, 1.72 mmol), cesium fluoride (1.31 g, 8.60 mmol) and dimethylsulfoxide (5 mL) was heated at 180° C. for 2 hours in a sealed tube. The reaction was cooled down, filtered through Celite® eluting with ethyl acetate and the filtrate was washed with water, dried over magnesium sulphate and the solvent removed under reduced pressure. The residue was purified by flash chromatography (40-70% acetone in hexanes) to give the title compound (0.11 g, 64%) as a brown foam.

1. customprepared
2. temperatureThe reaction was cooled down
3. filtrationfiltered through Celite®
4. washeluting with ethyl acetate
5. washthe filtrate was washed with water
6. dry with materialdried over magnesium sulphate
7. customthe solvent removed under reduced pressure
8. customThe residue was purified by flash chromatography (40-70% acetone in hexanes)