HCID 86702330, compound → HCID 86702331, compound

Participants

Reaction Steps

N6-[(1S)-1-(5-Fluoropyridin-2-yl)ethyl]-N2-(2-methoxypyridin-3-yl)-3-nitropyridine-2,6-diamine (Preparation 22b, 131 mg, 0.34 mmol) was added to a suspension of palladium on carbon (10%, 18 mg) in ethanol (5 mL) and the reaction mixture was stirred at ambient temperature under a hydrogen atmosphere. After 7 hours, additional palladium on carbon was added (18 mg) and the reaction mixture was stirred at ambient temperature under a hydrogen atmosphere for further 15 hours. The mixture was then filtered through Celite® and the filter cake was washed with ethanol (5×10 mL). The combined filtrate and washings containing the title compound as a methanolic solution was used in the next synthetic step without further purification.

Provenance & Evidence