Formamidine acetate → HCID 86702332, compound

Participants

Reaction Conditions

Reaction Steps

Formamidine acetate (141 mg, 1.35 mmol) was added to a solution of N6-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]N2-(2-methoxypyridin-3-yl)pyridine-2,3,6-triamine in ethanol (Preparation 22c) and the resulting mixture was heated at 85° C. for 5 hours. The reaction was cooled down and diluted with ethyl acetate (50 mL), washed with brine (2×100 mL) and water (50 mL), dried over magnesium sulphate and the solvent removed under reduced pressure. The residue was purified by flash chromatography (9:1 hexanes/ethyl acetate to 100% ethyl acetate) to give the title compound (104 mg, 84%, two steps) as a green oil.

Provenance & Evidence