5-Chloro-2-methoxy-3-nitropyridine → 5-Chloro-2-methoxypyridin-3-amine

Participants

Reaction Steps

Zinc bromide (226 mg, 1 mmol) and platinum on carbon (5%, 491 mg, 2.52 mmol) were added to a solution of 5-chloro-2-methoxy-3-nitropyridine (Preparation 23a, 950 mg, 5.04 mmol) in ethyl acetate (15 mL) and the reaction mixture was stirred at ambient temperature for 5 hours under a hydrogen atmosphere. The mixture was then filtered through Celite® and the filter cake was washed with methanol. The combined filtrate and washings were concentrated to give the title compound (820 mg, 100%) as a white solid.

Provenance & Evidence