HCID 86702335, compound → HCID 86702334, compound

Participants

Reaction Steps

A solution of N2-(5-chloro-2-methoxypyridin-3-yl)-N6-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-3-nitropyridine-2,6-diamine (Preparation 24b, 160 mg, 0.38 mmol) in ethyl acetate (11 mL) was hydrogenated using a H-Cube® Continuous-flow hydrogenation reactor and a Raney®-Nickel catalyst cartridge under a 80 bar pressure (flow=0.3 ml/min). Solvent was then concentrated to dryness under reduced pressure to yield the title compound (100 mg, 64%) as a green oil which was used in the next synthetic step without further purification.

Provenance & Evidence