Hydrochloric Acid → 3-Fluoro-4-[3-methyl-4-(2-phenyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol

Participants

Reaction Steps

178 mg 4-[6-(2-fluoro-4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-3-phenyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 3 ml dry 1,4-dioxane and 2 ml HCl (4N in 1,4-dioxane) was added. After stirring the reaction at r.t. for 30 min the volatiles were removed in vacuo and the resulting residue was purified by preparative HPLC (C18 column, acetonitrile/water gradient). 63 mg (51%) of the title compound were obtained.

Provenance & Evidence