HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Dimethyl-1-(phenylmethyl)piperazine → (4-Benzyl-2,2-dimethyl-piperazin-1-yl)-[6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Dimethyl-1-(phenylmethyl)piperazine | HCID 59485352 | — |
| Reactant | 6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid | HCID 86680321 | — |
| Product | (4-Benzyl-2,2-dimethyl-piperazin-1-yl)-[6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-methanone | HCID 90013862 | 97.4% |
Reaction Steps
In analogy to Example 1 step (d) 300 mg 6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid was reacted with 160 mg 1-benzyl-3,3-dimethyl-piperazine to obtain 410 mg (94%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133181B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-09f3038a24b4483da38158cbb581cc7c |
| Source note | uspto-grants-2015_09 |