4-(4-Benzyl-2,2-dimethyl-piperazin-1-ylmethyl)-6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine → 4-[4-(2,2-Dimethyl-piperazin-1-ylmethyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-3-fluoro-phenol

Participants

Reaction Steps

200 mg 4-(4-benzyl-2,2-dimethyl-piperazin-1-ylmethyl)-6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine was dissolved in 6 ml methanol and purged with argon. 18 mg Palladium (10% on charcoal) was added and the mixture was hydrogenated at 3 bar and r.t. for 16 h. The catalyst was filtered off and the solvents were evaporated. 130 mg (45%) of the title compound were obtained.

Provenance & Evidence