HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 308103, compound → (4-Benzyl-2,2,5,5-tetramethyl-piperazin-1-yl)-{3-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 308103 | HCID 308103 | — |
| Reactant | 3-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid | HCID 90013697 | — |
| Product | (4-Benzyl-2,2,5,5-tetramethyl-piperazin-1-yl)-{3-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl}-methanone | HCID 90013780 | 76% |
Reaction Steps
In a similar manner as in Exampe 40 step (b) 400 mg of 3-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid was reacted with 212 mg 1-benzyl-2,2,5,5-tetramethyl-piperazine to obtain 450 mg (76%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133181B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-ce5b5696c8ab45449ecd03655a2b5913 |
| Source note | uspto-grants-2015_09 |