1-Benzyl-5,5-diethyl-2,2-dimethyl-piperazine → HCID 178436592, compound

HRID 2279103Notes

Reaction equation

HRID 2279103 reaction equation
CC1C2C(=NC(C3C=CC(O)=CC=3)=CC=2CN2CC(C)(C)NCC2(C)C)NN=1.[CH3:29][C:30]1[C:38]2[C:37]([C:39](O)=O)=[CH:36][C:35]([C:42]3[CH:47]=[CH:46][C:45]([O:48]C4CCCCO4)=[CH:44][CH:43]=3)=[N:34][C:33]=2[N:32](C2CCCCO2)[N:31]=1.C([N:68]1[CH2:73][C:72]([CH2:76][CH3:77])([CH2:74][CH3:75])[NH:71][CH2:70][C:69]1([CH3:79])[CH3:78])C1C=CC=CC=1>>[CH2:76]([C:72]1([CH2:74][CH3:75])[CH2:73][NH:68][C:69]([CH3:79])([CH3:78])[CH2:70][N:71]1[CH2:39][C:37]1[CH:36]=[C:35]([C:42]2[CH:43]=[CH:44][C:45]([OH:48])=[CH:46][CH:47]=2)[N:34]=[C:33]2[NH:32][N:31]=[C:30]([CH3:29])[C:38]=12)[CH3:77]

Participants

4

Reactant 3

HCID 648606481-Benzyl-5,5-diethyl-2,2-dimethyl-piperazineHCID 900136973-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidHCID 178434387HCID 178434387, compound

Product 1

HCID 178436592HCID 178436592, compound

Procedure

4-[4-(2,2-diethyl-5,5-dimethyl-piperazin-1-ylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol was synthesized in analogy to Example 49 (4-[3-Methyl-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol) starting from 3-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid and 1-benzyl-5,5-diethyl-2,2-dimethyl-piperazine.

Sources & evidence

ORD record
ord-8531f8d72bee4a20b85f3c94701c9205
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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