HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-2,2,5-trimethylpiperazine → 4-[3-Methyl-4-(2,5,5-trimethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-2,2,5-trimethylpiperazine | HCID 64846103 | — |
| Reactant | 3-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid | HCID 90013697 | — |
| Reactant | HCID 178434387 | HCID 178434387 | — |
| Product | 4-[3-Methyl-4-(2,5,5-trimethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol | HCID 178434386 | — |
Reaction Steps
4-[3-Methyl-4-(2,5,5-trimethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol was synthesized in analogy to Example 49 (4-[3-Methyl-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol) starting from 3-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid and 1-benzyl-2,2,5-trimethyl-piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133181B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-cacfb46bedbf4a23b78bbc88f54361fa |
| Source note | uspto-grants-2015_09 |