Aluminium lithium hydride → HCID 136623188, compound

Participants

Reaction Conditions

Reaction Steps

600 mg of ((2S,5R)-4-benzyl-2,5-dimethyl-piperazin-1-yl)-[6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-methanone were dissolved in 10 ml of THF. Under Argon-atmosphere, 1.1 ml of lithium aluminium hydride (2.4M in THF) was added and the reaction was heated to reflux for 2 h. The reaction was then cooled to 0° C., and quenched by the addition of 5 ml EtOAc and 5 ml water. The mixture was filtered over celite by suction and washed with EtOAc. The solvents were removed in vacuo and 500 mg (86%) of the title compound were obtained and used without further purification.

Provenance & Evidence