HCID 136623188, compound → HCID 178434391, compound

Participants

Reaction Steps

585 mg 4-[4-((2S,5R)-4-benzyl-2,5-dimethyl-piperazin-1-ylmethyl)-3-methyl-1-(tetra-hydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol were dissolved in 10 ml methanol and 5 ml of THF and purged with argon. 50 mg Palladium (10% on charcoal) were added and the mixture was hydrogenated at r.t. for 15 h. The catalyst was filtered off and the solvents were evaporated. The residue was taken up in ethyl acetate and 1N aqueous hydrochloric acid. The phases were separated and the aqueous phase was washed with dichloromethane. To the aqueous phase was then added 1 ml concentrated aqueous hydrochloric acid and the reaction was left standing overnight. After freeze-drying 390 mg (90%) of the title compound were obtained.

Provenance & Evidence