反应详情

1.10 g of [6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-methanol were dissolved in 5 ml of dichloromethane. At 0° C. 0.52 g Dess-Martin-Periodinane were added. After 16 h at r.t. the reaction was diluted with dichloromethane, and washed subsequently with 1 N aqueous hydrochloric acid and sat. aqueous sodium hydrogencarbonate solution. The organic layer was then dried over sodium sulphate, filtered and concentrated in vacuo to yield 1.10 g (100%) of the crude title compound, which was used without further purification in the next step.

1. customAt 0° C
2. washwashed subsequently with 1 N aqueous hydrochloric acid and sat. aqueous sodium hydrogencarbonate solution
3. dry with materialThe organic layer was then dried over sodium sulphate
4. filtrationfiltered
5. concentrationconcentrated in vacuo