HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,5,5-Tetramethylmorpholine → 3-Fluoro-4-[3-methyl-4-(2,2,5,5-tetramethyl-morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,5,5-Tetramethylmorpholine | HCID 28806233 | — |
| Reactant | 6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid | HCID 86680321 | — |
| Reactant | 3-Fluoro-4-[3-methyl-4-(2-phenyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol | HCID 178434413 | — |
| Product | 3-Fluoro-4-[3-methyl-4-(2,2,5,5-tetramethyl-morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol | HCID 178434411 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1 steps (d) to (g) starting from 6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid and 2,2,5,5-tetramethyl-morpholine, however, in the last step only the THP-protecting group on the pyrazole ring was removed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133181B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-109e2ae26fbe4ef08f45c70eb95340f0 |
| Source note | uspto-grants-2015_09 |