反应详情

To a solutuion of 130 mg [6-bromo-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-methanol in 5 ml of dry DCM at 0° C. 77 μl of TEA were added, after 10 min followed by the addition of 60 mg of methanesulfonyl chloride. After 20 min at 0° C. the reaction was brought to rt and extracted with sat. aqueous ammonium chloride solution. The organic layer was separated, dried over sodium sulphate and freeze-dried to obtain 138 mg (85%) of the title compound as a crude product, which was used without purification in the subsequent step.

1. customat 0° C
2. extractionextracted with sat. aqueous ammonium chloride solution
3. customThe organic layer was separated
4. dry with materialdried over sodium sulphate
5. customfreeze-dried