Hydrochloric Acid → HCID 178434394, compound

Participants

Reaction Steps

60 mg of 4-{[6-(4-methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-amino}-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester were dissolved in 1.2 ml of 1,4-dioxane and treated with 1.5 ml of hydrochloric acid (4 M in dry dioxane). After standing at rt for 48 h the volatiles were removed in vacuo, The residue was triturated with dioxane and the resulting solid was isolated by suction. 30 mg (74%) of the title compound were obtained.

Provenance & Evidence