Formaldehyde → HCID 178434402, compound

HRID 2279131Notes

Reaction equation

HRID 2279131 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([OH:35])[CH:5]=[CH:6][C:7]=1[C:8]1[N:13]=[C:12]2[NH:14][N:15]=[C:16]([CH3:17])[C:11]2=[C:10]([CH2:18][N:19]2[CH2:24][C:23]([CH3:26])([CH3:25])[N:22]([CH2:27]CC(F)(F)F)[CH2:21][C:20]2([CH3:34])[CH3:33])[CH:9]=1.[CH3:36][C:37]1(C)N(CC2C=C(C3C=CC(O)=CC=3F)N=C3NN=C(C)C=23)CC2(CCCC2)NC1.C=O>>[F:1][C:2]1[CH:3]=[C:4]([OH:35])[CH:5]=[CH:6][C:7]=1[C:8]1[N:13]=[C:12]2[NH:14][N:15]=[C:16]([CH3:17])[C:11]2=[C:10]([CH2:18][N:19]2[CH2:24][C:23]3([CH2:26][CH2:37][CH2:36][CH2:25]3)[N:22]([CH3:27])[CH2:21][C:20]2([CH3:33])[CH3:34])[CH:9]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 178434401HCID 178434401, compoundHCID 178434405HCID 178434405, compound

Product 1

HCID 178434402HCID 178434402, compound

Procedure

The title compound was prepared in analogy to Example 65 (3-Fluoro-4-{3-methyl-4-[2,2,5,5-tetramethyl-4-(3,3,3-trifluoro-propyl)-piperazin-1-ylmethyl]-1H-pyrazolo[3,4-b]pyridin-6-yl}-phenol) using 4-[4-(8,8-Dimethyl-6,9-diaza-spiro[4.5]dec-9-ylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-3-fluoro-phenol and aqueous formaldehyde.

Sources & evidence

ORD record
ord-69d87830e47541e8b9be92e8947addab
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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