HCID 178434409, compound → HCID 178434408, compound

Participants

Reaction Steps

63 mg of 4-{4-[4-(2-Benzyloxy-ethyl)-2,2,5,5-tetramethyl-piperazin-1-ylmethyl]-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl}-3-fluoro-phenol were dissolved in 5 ml of methanol. 2 mg of Pd/C (10%) were added and the mixture was hydrogenated for 5 h at 5 bar. Then 1 ml of hydrorchloric acid (1M in dioxane) was added and the mixture was again hydrogenated at 5 bar for 24 h. The reaction was filtrated and concentrated in vacuo. After purification by HPLC 1 mg of the title compound was obtained.

Provenance & Evidence