HCID 178434406, compound → HCID 178434407, compound

HRID 2279133Notes

Reaction equation

HRID 2279133 reaction equation
CC1(C)[O:6][C@@H:5]([CH2:7][N:8]2[C:13]([CH3:15])([CH3:14])[CH2:12][N:11]([CH2:16][C:17]3[CH:22]=[C:21]([C:23]4[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][C:24]=4[F:30])[N:20]=[C:19]4[NH:31][N:32]=[C:33]([CH3:34])[C:18]=34)[C:10]([CH3:36])([CH3:35])[CH2:9]2)[CH2:4][O:3]1>O1CCOCC1.O>[F:30][C:24]1[CH:25]=[C:26]([OH:29])[CH:27]=[CH:28][C:23]=1[C:21]1[N:20]=[C:19]2[NH:31][N:32]=[C:33]([CH3:34])[C:18]2=[C:17]([CH2:16][N:11]2[C:10]([CH3:35])([CH3:36])[CH2:9][N:8]([CH2:7][C@H:5]([OH:6])[CH2:4][OH:3])[C:13]([CH3:15])([CH3:14])[CH2:12]2)[CH:22]=1

Participants

4

Reactant 1

HCID 178434406HCID 178434406, compound

Product 1

HCID 178434407HCID 178434407, compoundYield 31.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

208 mg 4-{4-[4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2,2,5,5-tetramethyl-piperazin-1-ylmethyl]-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl}-3-fluoro-phenol were dissolved in 2 ml of dioxane and 0.3 ml of water. 2 ml of hydrorchloric acid (4M in dioxane) were added. After 1.5 h at rt the volatiles were removed in vacuo and the residue was purified by HPLC. 60 mg of the title compound ewre obtained.

Workup

  1. customAfter 1.5 h at rt the volatiles were removed in vacuo
  2. customthe residue was purified by HPLC

Sources & evidence

ORD record
ord-a2168188b1d042a4943d155b8e0a6fd3
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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