Acetoxyacetyl chloride → HCID 178434410, compound

HRID 2279135Notes

Reaction equation

HRID 2279135 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]2[NH:15][N:16]=[C:17]([CH3:18])[C:12]2=[C:11]([CH2:19][N:20]2[C:25]([CH3:27])([CH3:26])[CH2:24][N:23]([C:28](=[O:32])[CH2:29][O:30]C)[C:22]([CH3:34])([CH3:33])[CH2:21]2)[CH:10]=1.FC1C=C(O)C=CC=1C1N=C2NN=C(C)C2=C(CN2CC(C)(C)NCC2(C)C)C=1.C(OCC(Cl)=O)(=O)C>>[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]2[NH:15][N:16]=[C:17]([CH3:18])[C:12]2=[C:11]([CH2:19][N:20]2[C:25]([CH3:27])([CH3:26])[CH2:24][N:23]([C:28](=[O:32])[CH2:29][OH:30])[C:22]([CH3:34])([CH3:33])[CH2:21]2)[CH:10]=1

Participants

4

Reactant 3

HCID 26297Acetoxyacetyl chlorideHCID 178434404HCID 178434404, compoundHCID 178496352HCID 178496352, compound

Product 1

HCID 178434410HCID 178434410, compound

Procedure

The title compound was prepared in analogy to Example 75 (1-{4-[6-(2-Fluoro-4-hydroxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2,5,5-tetramethyl-piperazin-1-yl}-2-methoxy-ethanone) using 3-fluoro-4-[3-methyl-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol and acetoxyacetyl chloride.

Sources & evidence

ORD record
ord-d98d73d7d15240aba14445a0845fcf24
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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