Methoxyacetyl chloride → HCID 178496386, compound

HRID 2279136Notes

Reaction equation

HRID 2279136 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]2[NH:15][N:16]=[C:17]([CH3:18])[C:12]2=[C:11]([CH2:19][N:20]2[C:25](C)(C)[CH2:24][N:23]([C:28](=[O:32])[CH2:29][O:30][CH3:31])[C:22]([CH3:34])([CH3:33])[CH2:21]2)[CH:10]=1.NC1(C)CCCN(CC2C=C(C3C=CC(O)=CC=3F)N=C3NN=C(C)C=23)C1.COCC(Cl)=O>>[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]2[NH:15][N:16]=[C:17]([CH3:18])[C:12]2=[C:11]([CH2:19][N:20]2[CH2:25][CH2:24][CH2:33][C:22]([NH:23][C:28](=[O:32])[CH2:29][O:30][CH3:31])([CH3:34])[CH2:21]2)[CH:10]=1

Participants

4

Reactant 3

HCID 96623Methoxyacetyl chlorideHCID 178434403HCID 178434403, compoundHCID 178496352HCID 178496352, compound

Product 1

HCID 178496386HCID 178496386, compound

Procedure

The title compound was prepared in analogy to Example 75 (1-{4-[6-(2-Fluoro-4-hydroxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2,5,5-tetramethyl-piperazin-1-yl}-2-methoxy-ethanone) using 4-[4-(3-Amino-3-methyl-piperidin-1-ylmethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-3-fluoro-phenol and methoxyacetyl chloride.

Sources & evidence

ORD record
ord-a1c6211a532d429bb3ce875e741c9137
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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