Methoxyacetyl chloride → HCID 178496357, compound

HRID 2279137Notes

Reaction equation

HRID 2279137 reaction equation
F[C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]2[NH:15][N:16]=[C:17]([CH3:18])[C:12]2=[C:11]([CH2:19][N:20]2[C:25](C)([CH3:26])[CH2:24][N:23]([C:28](=[O:32])[CH2:29][O:30][CH3:31])[C:22]([CH3:34])([CH3:33])[CH2:21]2)[CH:10]=1.[CH3:35][C:36]1C2C(=NC(C3C=CC(O)=CC=3)=CC=2CN2CC3(CCCC3)NCC2C)NN=1.COCC(Cl)=O>>[OH:8][C:6]1[CH:7]=[CH:2][C:3]([C:9]2[N:14]=[C:13]3[NH:15][N:16]=[C:17]([CH3:18])[C:12]3=[C:11]([CH2:19][N:20]3[CH2:21][C:22]4([CH2:33][CH2:36][CH2:35][CH2:34]4)[N:23]([C:28](=[O:32])[CH2:29][O:30][CH3:31])[CH2:24][CH:25]3[CH3:26])[CH:10]=2)=[CH:4][CH:5]=1

Participants

4

Reactant 3

HCID 96623Methoxyacetyl chlorideHCID 178434385HCID 178434385, compoundHCID 178496352HCID 178496352, compound

Product 1

HCID 178496357HCID 178496357, compound

Procedure

The title compound was prepared in analogy to Example 75 (1-{4-[6-(2-Fluoro-4-hydroxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2,5,5-tetramethyl-piperazin-1-yl}-2-methoxy-ethanone) using 4-[3-Methyl-4-(8-methyl-6,9-diaza-spiro[4.5]dec-9-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol and methoxyacetyl chloride.

Sources & evidence

ORD record
ord-cfd4b0e9dddf4aeea717cca424c177f0
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

Loading…