Formaldehyde → HCID 178434388, compound

HRID 2279145Notes

Reaction equation

HRID 2279145 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([C:28]3[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=3)=[CH:8][C:9]=2[CH2:11][N:12]2[CH2:17][C:16]([CH3:19])([CH3:18])[N:15]([CH2:20]CC(F)(F)F)[CH2:14][C:13]2([CH3:27])[CH3:26])[NH:4][N:3]=1.C=O>>[CH3:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([C:28]3[CH:29]=[CH:30][C:31]([OH:34])=[CH:32][CH:33]=3)=[CH:8][C:9]=2[CH2:11][N:12]2[CH2:17][C:16]([CH3:18])([CH3:19])[N:15]([CH3:20])[CH2:14][C:13]2([CH3:27])[CH3:26])[NH:4][N:3]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 178434389HCID 178434389, compound2×

Product 1

HCID 178434388HCID 178434388, compound

Procedure

The title compound was synthesized in analogy to Example 83 (4-{3-Methyl-4-[2,2,5,5-tetramethyl-4-(3,3,3-trifluoro-propyl)-piperazin-1-ylmethyl]-1H-pyrazolo[3,4-b]pyridin-6-yl}-phenol), steps (f) and (g) using aqueous formaldehyde.

Sources & evidence

ORD record
ord-556efcd1455741bead008ef18f324c60
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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